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The activities of these enzymes reduce the availability of amino acids (for example, tryptophan, arginine, histidine, and threonine) to surrounding T cells, inhibiting mTOR signaling via the lipid phosphatase PTEN and blocking the proliferation of Teff cells, thus promoting Treg cell induction (183)
Mulay SR, Thomasova D, Ryu M, Kulkarni OP, Migliorini A, Bruns H
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doi: 10.1016/j.phrs.2014.08.002 94 ToughDFBorrowPSprentJ
Eng Life Sci (2021) 21(11):73952